Tuesday, February 26, 2013

Swan Tower - How to write a long fantasy series

02:39 pm - How to write a long fantasy series

It took three years and two months rather than the two years I initially planned, but I have, at very long last, finished the Wheel of Time re-read and analysis. And as I promised quite some time ago, we?ll end with what I?ve learned.

This post, unlike the others, is not WoT-specific. I?ll be referencing the series, because it?s the primary source of my thoughts on this topic, but the point here is to talk about the specific challenges of writing a long epic fantasy series -- here defining ?long? as ?more than a trilogy, and telling one ongoing story.? (So something like Mercedes Lackey?s Valdemar books wouldn?t count, since they?re a conglomeration of multiple trilogies.) My points probably also apply to non-fantasy series, but other genres are much less likely to attempt multi-volume epics on this scale, so I?m mostly speaking to my fellow fantasists.

I do not pretend this is in any way, shape, or form a recipe for commercial success with an epic fantasy series. After all, most of this is a checklist of errors I feel Jordan made, and you could paper the walls of Tor?s offices in fifty-dollar bills with the cash he made for them. Nor am I claiming artistic failure awaits if you fail to heed this advice; you might squeak through on luck, or just really good storytelling instinct. But I do feel that bearing these points in mind can help the would-be writer of an epic series avoid falling off some of the more common and perilous cliffs.

With all of that intro material out of the way, let?s get to it.


On the basis of my re-read, and comparing to other series that attempt similar tasks, I have come to believe there is a single, fundamental principle, underlying all the other points I?ll make throughout this post, which governs the author?s ability to keep the narrative from spinning wildly out of control, to the detriment of their story.

It?s simple:

PICK A STRUCTURE, AND STICK TO IT.

Most of us, when we set out to write a novel, have at least a vague sense of how long it?s going to be. We can be off in that estimate -- In Ashes Lie ran about thirty thousand words longer than I originally intended -- but generally speaking, you know that you?re aiming for 60K or 100K or 200K, and you use that to guide a thousand decisions you make along the way. Should you introduce new subplots, or is it time to start tying things up? Does your protagonist?s next action need some complications along the way, or would it be better to just handle it offscreen and move on to more important things? Can you bring in a new character for this strand, or should you find a way to take care of things with the characters you already have? These are questions of pacing, and we?ll come back to that a bunch of times along the way. But you can?t gauge your pace when you don?t know how long the race will be: at best, you?ll end up going through the whole thing with a steady, slogging, workhorse pace that (to switch metaphors) loses all sense of dynamics.

Pick a structure, and stick to it.

By ?a structure? I mostly mean ?a set number of books,? though I allow that there might be other ways to conceive of it. J.K. Rowling knew the Harry Potter series would be seven books, and each book would span one academic year at Hogwarts (plus or minus a little time before or after). The actual size of those books varied wildly, and you can certainly make the argument that she would have benefited from tighter editing as the word-count ballooned. But does anybody think that situation would have been improved by her saying, ?There?s an awful lot of stuff to deal with in book five; I think I should split it in two?? I doubt it. (The decision to split the final film was likely drive as much by financial aspirations as artistic, if not more so. And oy vey is that the case with the two Breaking Dawn movies. But by then the material was set; the end was in sight.)

I haven?t read Steven Erickson?s Malazan books, but I?m told he set out to write a ten-book series, and that?s what he delivered. And you know what? Based on what I?ve heard from readers, some of them thought it was great, some of them thought it was flawed, but none of them thought it was the trainwreck of apocalyptically bad pacing the Wheel of Time turned into. Whether or not you liked where the story was going, it was indubitably going somewhere, and at a reasonable clip.

A Song of Ice and Fire, by contrast, was supposed to be a trilogy. Then a quartet. Then a sextet. Then A Dance With Dragons got too long, so Martin split it and now the series is a septet. In a recent interview, he said it might run to eight books instead. Step by step, I can see him walking into the same swamp Jordan got lost in.

Tom Smith discusses this in his essai Zeno?s Mountains, wherein he cites David Eddings saying that a man who?s never walked a mile has no real sense of how far a mile is. Most of us learn how much Stuff goes into a novel by writing one; we learn how much Stuff goes into a trilogy by doing the same. How many of us ever write more than one seven- or nine- or ten-book series, though? Jordan never got a chance to learn from his first attempt and do better the second time. Martin likely won?t, either.

Smith says, ?I do not know of any general solution to this problem; perhaps no general solution is possible.? I say there is a solution, and its name is Discipline.

As answers go, it isn?t perfect; keeping your series confined within its intended boundaries may result in a less satisfying arc for various plots than you would get if you let them stretch out to their fullest. But letting them stretch may very well be detrimental to other aspects of the story. Keep one eye always on the larger picture, and know what must be accomplished by the end of the current book for you to remain on schedule.

Doing so may require some ruthless editing. And it?s entirely possible that such editing won?t be in your best commercial interests: it costs time and effort, laid against the odds that allowing the story to sprawl will translate into more money for you and your publisher alike. From the standpoint of craft, though, rather than the bottom line:

Pick a structure, and stick to it.

Continuing onward from there, I have learned several other salutary lessons, most (if not all) of them standing on that structural foundation.

1. Control your points of view.

A friend of mine, in discussion regarding an epic fantasy series she?d like to write, proposed that this should be the number-one item on my list. I put it at number two because I believe structure is one of the major yardsticks by which the decision to add a new pov character should be measured.

I could point to any number of cautionary examples from the Wheel of Time (goddamed Vilnar Barada comes to mind, or Alteima), but I think it?s best to look at the moment where I first noticed Jordan going wrong. That would be the pov scene for Jaichim Carridin in The Shadow Rising, the fourth book of the series -- the one where the branching nature of the story is at its strongest, right before passing from being a feature into being a nigh-fatal bug.

For those who aren?t familiar with the Wheel of Time, Carridin is a minor villain character who gets four pov scenes in the entire series. In this particular scene, we discover that he?s scheming with Liandrin (another minor villain; she gets four pov appearances, too) on behalf of one of the factions he serves, and with the King of Tarabon on behalf of a different faction. Which sounds good, except that the key word in that sentence is ?discover? rather than ?scheme? -- relatively little action takes place. Most of Carridin?s 3,194 words are spent on him thinking about stuff: the current political situation in the city, the current political situation outside the city, the way his evil overlords have been slaughtering his family one member at a time to motivate him, etc.

Some of the information that appears in this scene also reaches us via different channels in the story. Other parts aren?t terribly relevant, because they don?t come to anything in the long run. Jordan could easily have cut this scene, and we would have lost very little of substance; the few salient details could have been brought in elsewhere, by other means.

But let?s pretend for a moment that the information here is actually vital. Does that justify spending time in the head of this minor villain?

No. Because here?s the thing: switching to Carridin is lazy. It?s the easiest way to tell us what the bad guys are doing -- and I do mean ?tell,? given that most of the scene is Carridin thinking rather than acting. Had Jordan restricted himself to a smaller set of pov characters, he would have been forced to arrange things so that his protagonists found out what Carridin was doing. In other words, they would have had to protag more. And that would have been a better story.

Every time you go to add a new point of view character, ask yourself whether it?s necessary, and then ask yourself again. Do we need to get this information directly, or see these events happen first-hand? Can you arrange for your existing protagonists to be there, or to find out about it by other means? Are you sure?

Given what I said above about sticking to your structure, there may indeed be times where it?s more word-efficient to jump to a new pov, rather than constructing a path by which your existing viewpoints can pick up the necessary threads. But be careful, because taking the lazy way out appears to be a slippery slope for authors. This page lists no less than sixty characters who get only a single pov scene each during the entirety of the Wheel of Time. Nineteen more get two apiece. Eleven get three, seven get four, and then the numbers start ticking upward faster, until our six primary characters have between fifty-seven and two hundred -- just to give you an idea of scale.

If I am counting correctly, this series has ONE HUNDRED TWENTY-NINE POINT OF VIEW CHARACTERS.

That is absurd.

Martin is starting to have a similar problem, albeit on a smaller scale. He has thirty-one viewpoint characters so far, according to this page. Fifteen of those -- nearly half! -- have been introduced or received pov in the last two books, and most of them have only one or two chapters apiece per book, well below the usual average for this series. One character in A Feast for Crows died at the end of his sole chapter, whereupon pov transferred to one of the people he?d been traveling with. Why not give that person viewpoint to begin with? Why not spend the pages developing that character, instead of the one who won?t be with us for long?

John Scalzi once pointed out the inexorable consequence of multiple points of view on pacing, which authors of long epics would do well to bear in mind. If you have a 120K book and one pov character, that?s a hundred and twenty thousand words forwarding that character?s story. If you split it evenly between two characters, they get 60K apiece. Four characters, and now each of them has only 30K in which to move forward. Pretty soon, it feels like not very much is happening with any one of them.

Of course, you can mitigate this to some extent by having those characters interact, so that A?s story is progressing even while we?re in B?s head. But that brings us to our next point . . . .

2. Control your subplots.

Once you have multiple pov characters, it?s easy to let them wander off from one another and start doing different things. This isn?t inherently bad; if you want to write a long epic fantasy series, you?re going to need a high degree of complexity. But if you lose sight of your structure, you?re liable to also lose sight of how many subplots is too many, and which ones are taking too long to resolve.

There are two ways to fall off this particular cliff. One is that you know X is going on in Y part of the world, but you?re afraid it won?t seem reasonable if you spring it on your reader at the point where X begins to affect the rest of the plot. (Or you just think it?s too shiny not to show, or whatever.) So you decide you need to show X happening -- and probably add a point of view to facilitate that. The other path starts with the point of view: having given a character pov rights, you feel consciously or subconsciously obligated to justify that decision. On a small scale, this leads to pointless crap like Vilnar Barada thinking about the girl he wants to marry; on a large scale, it leads to things like the Shaido Plot From Hell, which I am convinced was Jordan creating makework so that Perrin would have something to do, and also justifying Faile as an ongoing pov character.

It may annoy readers (especially when you do it badly), but I?ve come around to the philosophy that you shouldn?t be afraid to give one or more of your characters a sabbatical from the story. The example of Jordan doing this right is Perrin?s absence from The Fires of Heaven: Perrin had just won a great victory and settled into some necessary but unexciting work of consolidation, so it was a dandy time to step away and focus on other characters. The story would not have been improved by inventing a subplot to fill that gap. The example of Jordan doing it wrong is Mat?s absence from The Path of Daggers: Mat had just been trapped under a collapsing wall during the invasion of a city. It turns out nothing interesting had been going on with him during his book-long absence . . . but given where the story had left off with him, readers expected a great deal more, and didn?t get it. If you?re going to step away, choose the point at which something has wrapped up, not begun.

Making up subplots to keep a character busy is a cascading problem. The proliferating points of view created and/or abetted new plot complexity, which meant the central ropes of the narrative got stretched out farther than they were meant to go. You can?t shelve your main character for three books, though, so Rand -- ostensibly the driving force of the whole shebang -- didn?t have a lot to do for a while other than run around micro-managing the politics of several nations, creating a lot of material that didn?t really add all that much to the story. It did add words, though, which meant Jordan had to find something for Perrin to do while Rand was occupied, so Faile got kidnapped by the Shaido, and then next thing you know, you?ve created a monstrosity of a plotline that 80% of your readers will hate with the fire of a thousand suns, and oh by the way now you need to keep all those secondary characters busy, too, the ones who started this problem in the first place. It?s the principle of the Lowest Common Multiple, played out in narrative form: if one character is cycling at 13 rpm and another is at 20, you have to keep rolling until you hit 260 to get them both wrapping up at the same time. And that way lies the ever-expanding tale.

If you stick to your structure, you at least have a metric by which to gauge whether a subplot is worth the time it will take to cover it. Of course, most of us can?t really eyeball an idea and say ?why yes, that?s fifteen thousand words? worth of subplot? -- would that we could! But this gets back to the ?ruthless editing? I mentioned before. If it starts stretching out too far, find a way to accomplish the necessary elements more efficiently. If you can?t do that, cut the subplot. Yes, it may be shiny, but is it worth throwing off the balance of everything else in the story?

3. Centralize.

This is closely-enough related to the previous point that I almost folded it in there, but I think it deserves to be pulled out and looked at on its own.

A long series is going to have a certain amount of sprawl, which is both necessary and desirable. But keep an eye on how long it?s been since your major characters interacted with one another. In the Wheel of Time, the fourth book was the first one where the main protagonists didn?t all come together for the finale; not coincidentally, it?s also the last one where the story?s sprawl felt truly effective. Something like eight or nine books passed without Rand and Perrin seeing one another, or Perrin and Mat. There was a point in the story where Rand, Mat, Perrin, Egwene, and Elayne were all in different places doing different things, and had been for some time; that?s five major plots rolling without reference to one another, in addition to the countless minor plots. We may also consider that Martin?s story and pacing have begun to fall apart as he lets his characters separate further and further: when?s the last time you had any two of Arya, Jon, Bran, Sansa, Catelyn, and Tyrion in the same place at the same time? (Not to mention Daenerys, off on the other side of the planet this entire time, or the host of other pov characters Martin has begun to introduce.)

Remember Scalzi?s point above: the more you fragment the perspective, the less forward movement each one gets per book. Remember my corollary: you can mitigate that by having the viewpoints overlap. Apart from the simple mathematics of pacing, this helps deal with the subplot issue, because you can keep important characters in the narrative by having A work with B on whatever it is B?s doing. (Or oppose it, or interfere with it, or whatever.) And it will assist in maintaining your structure, because if Aragorn?s got to be at the Black Gates when Frodo arrives at Mount Doom, then you?ve got to get that Pelennor thing done on schedule, which means not letting the Paths of the Dead episode overstay its welcome.

(Note that I am NOT holding up Tolkien as a model for how to construct the kind of narrative I?m talking about here. His approach was to ignore half his story for half a book, which isn?t a tactic that will serve any modern author very well. But Lord of the Rings is familiar enough to serve as a useful example.)

So yes. By all means let your characters wander off and do their own thing . . . but not for too long. Bring them back together periodically, and look for ways to get multiple stones to work together on killing that bird.

4. The further you go, the less you have to show your math.

This is less tied into the structural base than the rest of my points; it?s more a simple matter of word bloat.

Early on in your story, it?s useful to show how your characters pull off their small accomplishments. It demonstrates their competence to us, if it?s something they?re supposed to be good at, or conversely shows them developing new skills, if they?ve been thrust into situations outside their usual depth. Or it establishes the realism of the world, or gives the reader information about a topic they may not know very well. All of that is perfectly fine.

But when you?re ten books into your series, you really don?t need to show the camp logistics of the army your hero has been in command of for the last four books. You don?t need to walk through every step of how the heroine, having attained her throne, arranges a meeting with some fellow sovereigns. You?ve already established that these are tasks well within their skill-set. We will not bat an eyelash if you go straight to the meeting, or have the army keep trucking along in good order. If you introduce some element that makes those tasks hard again, then by all means show how the new challenge is overcome -- but even then, you?re allowed to only focus on the challenging part, and let the routine stuff go.

Because in theory, the further you go into your series, the more exciting the story should be. Tensions mount! We?re building toward the climax! Now is not the time to stop and do the simple math all over again. Think of it like a geometry proof: once you?ve proved the basic theorems, you?re allowed to just cite them and move on, rather than having to go through every step every time.

One of the corollaries to this is more debatable. Re-reading the Wheel of Time, I was struck by how many times the story explains Min?s visions; it felt unnecessarily repetitive to me. Arguably, however, that sort of repetition is necessary, because some readers may not have read the previous book in a long time, and may have forgotten who Min is and what she can do. (Or they may have picked up the third book without having read the first two, though I tend to be of the opinion that people who do that deserve what they get. I note that many series, including both the Wheel of Time and Harry Potter, eventually give up on holding people?s hands -- it just takes a while.) This is more a matter of exposition than showing the narrative math, and I?ll allow that some amount of reinventing the wheel may be required. But keep an eye on it anyway, and try to keep it to a minimum.

There are many other things I could say about the flaws in the Wheel of Time, or in other long series. But these are the main points, the ones I think are universally applicable, rather than specific to a particular narrative -- along with, of course, the basic lessons of good writing, like not using twenty words where five will do. A story?s quality depends heavily on its shape, on the timing of various twists and revelations, the pacing of its arcs and the rate at which the characters grow; and good shape rarely happens by accident, especially on a large scale. Ergo, I firmly believe that you need some fixed points by which to navigate during your journey. Know how many books you?re going to write, hammer in a couple of pegs to say that certain events will happen at certain points, and then hold to your course. If you stray from the path, you may never find your way out of the woods.

Rumor has it, of course, that Jordan was asked to stretch the series out, because it was making so much money. I have no idea if that?s true. But as I said at the start, my concern here is not the commercial success of a series; I?m addressing the story itself.

I?m speaking, mind you, as someone who has yet to write a series longer than four books (and those structured almost entirely as stand-alones). This is all based on my observations of other people?s efforts, not my own experience. But as I said to Tom Smith in the comments to ?Zeno?s Mountains,? there?s not enough time in life to screw it up yourself for a dozen books, and then to do better afterward. If you want to write a long series and not have it collapse in the middle like a badly-made souffle, you have to learn from other people?s mistakes.

This entry was also posted at http://swan-tower.dreamwidth.org/577881.html. Comment here or there.

Source: http://swan-tower.livejournal.com/580795.html

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Exclusive: Juniper mulls next move after asset sale talks falter - sources

NEW YORK (Reuters) - Juniper Networks Inc is reviewing its enterprise-focused networking business after talks fell through late last year to sell assets, including security unit NetScreen Technologies, several sources close to the matter told Reuters.

The world's No. 2 networking gear maker is mulling options that could include acquisitions to bolster the security and enterprise business, with a longer-term view of a sale or spin-off, two of the sources said. For acquisition financing it could decide to raise cash through a private sale of equity, the sources familiar with the company's thinking said.

From summer to fall of 2012, San Jose, California-based Juniper discreetly contacted about half a dozen competitors to test the appetite for its assets that handle networking for enterprise clients, two sources close to the matter said.

At the time, rumors were rife that major storage provider EMC Corp was also in talks to buy Juniper, though EMC CEO Joe Tucci has since dismissed any interest in buying a networking company.

Investment banks have not been hired by Juniper to assist in the review, the sources said. Goldman Sachs has helped the company on prior deals.

A spokesman for Goldman declined to comment.

Among the assets pitched last fall was NetScreen, a maker of firewall technology that Juniper bought in 2004 for $4 billion. But the interest was underwhelming, with parties walking away after concluding that Juniper's enterprise-oriented assets lacked innovation and growth, the sources said.

The company, which in October announced a 5 percent cut in its workforce, declined to comment on what a spokeswoman called rumors and speculation.

Asked at Mobile World Congress in Barcelona on Tuesday whether the company has plans to sell NetScreen or other parts of the business, Chief Executive Kevin Johnson said: "No, if you look at the acquisitions we have done, we're a buyer not a seller."

(Reporting By Nadia Damouni and Nicola Leske; Additional reporting Paul Sandle; Editing by Edwin Chan, Edward Tobin and David Gregorio)

Source: http://news.yahoo.com/exclusive-juniper-mulls-next-move-asset-sale-talks-182934262--sector.html

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Sunday, February 24, 2013

Israel-Initiated Secret Talks with Turkey Failed

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Source: http://www.israelnationalnews.com/News/Flash.aspx/262798

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Facebook Graph API not returning friends' photos

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Source: http://stackoverflow.com/questions/15045153/facebook-graph-api-not-returning-friends-photos

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Monkey-mothering 24-hour chore for Colombian woman

A 15-day-old night monkey is feed by a veterinarian at a temporary shelter west of Bogota, Colombia, Monday, Feb. 18, 2013. Sponsored by Bogota's Ministry of Environment, the shelter receives between 3,000 and 3,500 wild animals a year; some seized from poachers and others found hurt. An estimated $560,000 U.S. dollars are spent in the recovery and care of these animals. Seventy percent of rescued animals are reintroduced to their habitat and the remaining 30% are sent to zoos around the country. (AP Photo/Fernando Vergara)

A 15-day-old night monkey is feed by a veterinarian at a temporary shelter west of Bogota, Colombia, Monday, Feb. 18, 2013. Sponsored by Bogota's Ministry of Environment, the shelter receives between 3,000 and 3,500 wild animals a year; some seized from poachers and others found hurt. An estimated $560,000 U.S. dollars are spent in the recovery and care of these animals. Seventy percent of rescued animals are reintroduced to their habitat and the remaining 30% are sent to zoos around the country. (AP Photo/Fernando Vergara)

Caretaker Marta Silva, right, and biologist Judith Cardenas look at a baby night monkey at a wildlife shelter in Bogota, Colombia, Thursday, Feb. 21, 2013. Silva works with the neonatal unit of Bogota's Wildlife Reception Center, part of the capital's environment ministry, where she has nurtured species ranging from birds to turtles to primates. Now she is looking after the night monkey of the genus Aotus that lives in the tropical forests of South America, including Colombia, Brazil and Ecuador. (AP Photo/Fernando Vergara)

A 15-day-old night monkey sits in a veterinarian's palm at a temporary shelter west of Bogota, Colombia, Monday, Feb. 18, 2013. Sponsored by Bogota's Ministry of Environment, the shelter receives between 3,000 and 3,500 wild animals a year; some seized from poachers and others found hurt. An estimated $560,000 U.S. dollars are spent in the recovery and care of these animals. Seventy percent of rescued animals are reintroduced to their habitat and the remaining 30% are sent to zoos around the country. (AP Photo/Fernando Vergara)

A 15-day-old night monkey clutches the fingers of a veterinarian at a temporary shelter west of Bogota, Colombia, Monday, Feb. 18, 2013. Sponsored by Bogota's Ministry of Environment, the shelter receives between 3,000 and 3,500 wild animals a year; some seized from poachers and others found hurt. An estimated $560,000 U.S. dollars are spent in the recovery and care of these animals. Seventy percent of rescued animals are reintroduced to their habitat and the remaining 30% are sent to zoos around the country. (AP Photo/Fernando Vergara)

Caretaker Marta Silva places a baby night monkey close to her chest after showing it to a news photographer at a wildlife shelter in Bogota, Colombia, Thursday, Feb. 21, 2013. The tiny night monkey is with Silva 24 hours a day, nestled in a wool pouch inside her coat or beside her while she sleeps. Silva works with the neonatal unit of Bogota's Wildlife Reception Center, part of the capital's environment ministry, where she has nurtured species ranging from birds to turtles to primates. Now she is looking after the night monkey of the genus Aotus that lives in the tropical forests of South America, including Colombia, Brazil and Ecuador. (AP Photo/Fernando Vergara)

BOGOTA, Colombia (AP) ? The tiny night monkey is with Martha Silva 24 hours a day, nestled in a wool pouch inside her coat or beside her while she sleeps. Eight times a day, she feeds milk to the five-inch baby like an attentive mother.

The long hours of monkey mothering don't bother the 54-year-old Colombian woman, she said, because she already raised two children.

"To me there is no difference. You have to look after each the same. When you give them the bottle, you have to make sure they don't choke," said Silva, who works with the neonatal unit of Bogota's Wildlife Reception Center, part of the capital's environment ministry.

Silva, who has children aged 20 and 30, began working at the center west of Bogota in 2000. She has nurtured species ranging from birds to turtles to primates.

"I carry them with me for a couple of months, in general, or the time that is required," she told The Associated Press. Her husband and daughter help her with the household chores and cooking while she is occupied with a baby animal.

Now she is looking after the night monkey, a member of the Aotus genus, which lives in the tropical forests of South America, including Colombia, Brazil and Ecuador. Night monkeys got their name because of their unusual nocturnal habits.

"When I'm working, I make sure he doesn't get out of the little bag I have. If there is sun, I take him out of the sun," she said.

Silva never gives her animal charges names so they don't become seen as pets. In the long term, the center aims to return them to the wild.

Her latest baby, a male night monkey with dark fur, beige brows and large, protruding brown eyes for night vision, arrived at the center on Feb. 4, weighing a scant 100 grams, about a quarter of a pound.

It was brought in by a man who said he found it abandoned on the side of a highway in Colombia's eastern plains near Meta province, said Judith Cardenas, the center's chief biologist. The monkey was about 5 days old when it arrived, and the man said he couldn't bring himself to leave it to die, Cardenas said.

Biologists at the center don't how this baby ended up being orphaned, but they say the mother may have been killed or perhaps the baby strayed off. Cardenas said Amazon-region monkeys are often hunted for meat, for experiments or as pets.

Silva, a pony-tailed woman with nails painted emerald green, made a small bag of brown and black cloth squares to hold the monkey, which is still too young to walk. They sleep together and Silva takes the monkey to the center each day on her bicycle, the baby snug in the wool bag.

Every three hours, the monkey must be fed delactosed milk with vitamins added, Cardenas said. In the wild, adult night monkeys eat leaves, insects and small lizards and frogs.

When he grows up, the monkey will weigh 800 to 900 grams (1.75 to 2 pounds) and stand about 34 centimeters (13.4 inches), Cardenas said, adding that he will look like "a medium-sized teddy bear."

She said this type of primate passes the first three or four months of its life clinging to or hanging from the back of a parent as it swings through the trees. Orphaned, they need a substitute mother, like Silva with her wool bag kept close to her body.

Having substitute mothers for orphaned baby monkeys has been used in other parts of the world and in Colombia in recent years.

The idea, Cardenas said, is to let a baby monkey grow and then place it in a large cage in the center, next to another monkey of the same species. If they accept being in the same cage together, the center and environmentalists will begin a process of trying to introduce them into the Amazon jungle with a monkey group.

"This kind of primate lives in family groups, with a father, mother and children ... They are a bit like us," said veterinarian Claudia Brieva, who coordinates the center's rescue and rehabilitation unit.

She said an older orphaned monkey can't be released alone into the jungle. A baby can be accepted by another family, however, or create its own, she said.

The International Union for Conservation of Nature lists a dozen types of night monkeys on its Red List of threatened species. Though none is listed as endangered, several are suffering declining populations.

In Colombia, Brieva said, "Their natural habitats are being destroyed by the expansion of the agricultural frontier, by the indiscriminate cutting o the forests and jungle."

Silva says she has raised two other baby monkeys and both of those were freed in different parts of the country. She hasn't heard anything about them since.

"It is like with a child. You are at peace because they are going to be in their natural habitat," she said.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/b2f0ca3a594644ee9e50a8ec4ce2d6de/Article_2013-02-22-Colombia-Orphaned%20Night%20Monkey/id-5c7d5ce833aa446ea9844aad80bfb5f6

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Ask Engadget: best / most 'open' e-book store?

Ask Engadget best  most open ebook store

We know you've got questions, and if you're brave enough to ask the world for answers, then here's the outlet to do so. This week's Ask Engadget inquiry is from Arthur, who's considering giving this new-fangled electronic book thing a go. If you're looking to ask one of your own, drop us a line at ask [at] engadget [dawt] com.

"During a recent move, I dumped a dozen boxes of books at goodwill, and have decided to give e-books a try. But what's the most "open" way to buy them? Me and my wife want to share titles (reasonable enough, given that we wouldn't buy two copies from a bookstore). As such, we'd like to open an account somewhere that will let us read on our various computers, PlayBook, iPad and Nook. Is there a store that you can suggest?"

Given your humble narrator's long-held resistance to e-books (and devotion to building a library of their own), this is one we're going to pass straight over to the Engadget community. So, dear friends, what's your opinion?

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Source: http://www.engadget.com/2013/02/23/ae-open-e-book-store/

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Saturday, February 23, 2013

Genomic detectives crack the case of the missing heritability

Feb. 22, 2013 ? Despite years of research, the genetic factors behind many human diseases and characteristics remain unknown. The inability to find the complete genetic causes of family traits such as height or the risk of type 2 diabetes has been called the "missing heritability" problem.

A new study by Princeton University researchers, however, suggests that missing heritability may not be missing after all -- at least not in yeast cells, which the researchers used as a model for studying the problem. Published in the journal Nature, the results suggest that heritability in humans may be hidden due only to the limitations of modern research tools, but could be discovered if scientists know where (and how) to look.

"The message of our study is that if you look hard enough you will find the missing heritability," said the senior researcher, Leonid Kruglyak, Princeton's William R. Harman '63 and Mary-Love Harman Professor in Genomics and a Howard Hughes Medical Institute Investigator. Kruglyak worked with first author Joshua Bloom, a Princeton graduate student; Wesley Loo, a 2010 Princeton graduate now a graduate student at Harvard University; Thuy-Lan Lite, Class of 2012, who is working at the National Institutes of Health for a year before starting graduate school; and Ian Ehrenreich, a past Princeton postdoctoral researcher now at the University of Southern California.

"We don't think there is some fundamental limitation -- such as that there are things we don't understand about how genes behave -- that is holding us back," Kruglyak said. "Instead, we should be able to detect the heritability in humans if we use the right tools."

Passed down from parent to child, genes determine not only eye color and other physical characteristics but also the risk of diseases. Some inherited diseases are caused by a mutation in a single gene. These single-gene disorders have well-defined patterns of inheritance that can be used to predict the chances that an individual will inherit the disease.

However, many diseases and physical traits arise due to multiple genes, multiple locations within genes, and even the regions of DNA between genes. Across the genome -- which is an individual's total genetic content -- small variations in DNA code can, when added together, increase or decrease the likelihood that a person will develop a disease or characteristic.

Height, for example, results from variations in DNA at multiple locations on the genome. Researchers have detected about 180 locations in the human genome where small alterations in the DNA code can have an influence on how tall or short a person is. Nonetheless, these locations account for only 13 percent of the expected contribution genetic code has on a person's height.

Type 2 diabetes also has missing heritability: About 40 identified genome locations are associated with the risk of developing the condition, but those account for only 10 percent of the estimated genetic influence. Finding the missing heritability for diseases like type 2 diabetes, Crohn's disease and schizophrenia could help inform prevention and treatment strategies.

In the present study, the researchers scanned the genomes of yeast cells for DNA variations -- which can be thought of as spelling errors in the four-letter DNA code -- and then matched those variations with qualities or characteristics inherited from the cells' parents. The researchers detected numerous DNA variations that, when added together, accounted for almost all of the offsprings' inherited characteristics, indicating that there was very little missing heritability in yeast.

Although the search for heritability was successful in yeast, finding missing heritability in humans is far more complicated, Kruglyak said. For example, interactions between genes can contribute to heritable traits, but such interactions are difficult to detect with genome-wide association studies (GWAS), which are the primary means by which geneticists look for DNA variations associated with diseases or traits. In addition, environmental factors such as nutrition also can influence gene activity, and these influences can be elusive to the genome-wide study. GWAS also may be inadequate at detecting common DNA spelling errors that have only small effects, or it may fail to find DNA variations that have a large effect but are rare.

The study sheds light on the role of nature (genetic factors) versus nurture (environmental factors) in determining traits and disease risk, according to Bert Vogelstein, director of the Ludwig Center at the Johns Hopkins University School of Medicine and a Howard Hughes Medical Institute Investigator.

"The nature versus nurture argument has been brewing for decades, both among scientists and the lay public, and 'missing heritability' has been problematic for the 'nature' component," said Vogelstein, who was not involved in the Princeton study.

"This beautiful study demonstrates that the genetic basis for heritability (nature) can be precisely defined if extensive, well-controlled experiments can be performed," Vogelstein said. "Though the results were obtained in a model organism, I would be surprised if they didn't apply, at least in part, to higher organisms, including humans."

Kruglyak said that one approach to finding the missing heritability in humans might be to apply genome-wide scans to large families, rather than focusing on large populations as is currently done. Family studies take advantage of the fact that the same genetic variations will be more common in families -- and thus easier to detect. However, the disadvantage of family studies is that the detected genetic variations may not be widespread in the population.

For the study in yeast, the team examined the offspring of two yeast cells, one that is commonly used in laboratory studies and the other in wine making. Although yeast usually reproduce asexually, under certain conditions, such as lack of food, two yeast cells will mate and produce offspring that, like human children, receive roughly half their genetic material from each parent. "Our study involves thousands of 'kids' from a single set of parents," Kruglyak said.

The team first sequenced the genomes of the two parent cells and then conducted scans for DNA variations in the genomes of 1,008 offspring. Yeast do not inherit height or disease risk from their parents, but they can inherit the ability to survive in adverse conditions. The researchers tested the parents and their offspring for the ability to grow under various conditions, including different temperatures, acidity levels, food sources, antibiotics, metal compounds, and in drugs such as caffeine.

The researchers then looked for associations between the DNA variations inherited from the parents and growth ability, and determined that the DNA variations accounted for nearly all of the resilience noted in the offspring.

The paper, "Finding the sources of missing heritability in a yeast cross," was published in Nature on Feb. 3, 2013. This work was supported by National Institutes of Health (NIH) grants R37 MH59520 and R01 GM102308; a James S. McDonnell Centennial Fellowship (L.K.); the Howard Hughes Medical Institute (L.K.); a National Science Foundation (NSF) fellowship (J.S.B.); an NIH postdoctoral fellowship F32 HG51762 (I.M.E.); and NIH grant P50 GM071508 to the Center for Quantitative Biology at the Lewis-Sigler Institute of Princeton University.

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The above story is reprinted from materials provided by Princeton University. The original article was written by Catherine Zandonella.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.


Journal Reference:

  1. Joshua S. Bloom, Ian M. Ehrenreich, Wesley T. Loo, Th?y-Lan V? Lite, Leonid Kruglyak. Finding the sources of missing heritability in a yeast cross. Nature, 2013; 494 (7436): 234 DOI: 10.1038/nature11867

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/most_popular/~3/bcvfBHxI58A/130222121047.htm

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